Open AccessInkjet printed drug-releasing polyelectrolyte multilayers for wound dressings
Author(s) -
Amy M. Peterson,
Huilin Yang
Publication year - 2017
Publication title -
aims materials science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.367
H-Index - 16
eISSN - 2372-0484
pISSN - 2372-0468
DOI - 10.3934/matersci.2017.2.452
Subject(s) - polyelectrolyte , materials science , substrate (aquarium) , gentamicin , fabrication , nanotechnology , chemical engineering , chemistry , polymer , composite material , antibiotics , medicine , biochemistry , oceanography , alternative medicine , pathology , engineering , geology
Inkjet printing was used as a novel processing method for the preparation of polyelectrolyte multilayers. Conformal, consistent coatings were formed on a cotton substrate. As a demonstration of a potential application of this processing method, polyelectrolyte multilayers were assembled on cotton for wound dressing. When loaded with gentamicin, these coatings demonstrated burst release of 50% of the loaded gentamicin over the first five hours, followed by consistent release of 0.15 µg/(cm2-h) for at least four days. Significant antimicrobial activity of the gentamicin-releasing polyelectrolyte multilayer-coated cotton was observed, with a zone of inhibition of 1.575 ± 0.03 cm. This result is comparable to the zone of inhibition for cotton soaked in gentamicin (1.75 ± 0.04 cm), indicating that the inkjet printing processing method does not degrade gentamicin. Inkjet printing shows promise as a low cost, versatile option for polyelectrolyte multilayer fabrication. Additionally, as a scalable process, inkjet printed samples exhibited consistent antibacterial function for over three months after preparation