Open AccessPrenatal exposures and exposomics of asthma
Author(s) -
HyeSeon Choi,
Mark T. McAuley,
David A. Lawrence
Publication year - 2015
Publication title -
aims environmental science
Language(s) - English
Resource type - Journals
eISSN - 2372-0352
pISSN - 2372-0344
DOI - 10.3934/environsci.2015.1.87
Subject(s) - exposome , asthma , biomarker , identification (biology) , medicine , metabolomics , computational biology , environmental health , biology , immunology , bioinformatics , ecology , genetics
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi