Open AccessMolecular mechanisms of intestinal inflammation leading to colorectal cancer
Author(s) -
Sonia Shastri,
Ravichandra Vemuri,
Nuri Gueven,
Madhur D. Shastri,
Rajaraman Eri
Publication year - 2017
Publication title -
aims biophysics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 12
ISSN - 2377-9098
DOI - 10.3934/biophy.2017.1.152
Subject(s) - colorectal cancer , medicine , inflammatory bowel disease , disease , cancer , ulcerative colitis , carcinogenesis , translational research , bioinformatics , pathology , biology
Inflammatory bowel disease (IBD) is recognized as a leading cause in the development of colorectal cancer (CRC). Inflammatory bowel disease associated colorectal cancer (IBD-CRC) is a growing healthcare burden, causing significant morbidity and mortality world-wide. In the present review, relevant preclinical models of IBD-CRC, a concise overview of potential molecular mechanisms that are involved and responsible for IBD associated colonic tumorigenesis along with the current and the future therapeutic approaches including the role of novel natural and synthetic compounds for the prevention and treatment of IBD-CRC are outlined. This review will benefit various clinicians and translational researchers working in the area of IBD-CRC to have a quick snap-shot of the ongoing trends in IBD-CRC research and discoveries