Open AccessThe gastrointestinal effects amongst Ehlers-Danlos syndrome, mast cell activation syndrome and postural orthostatic tachycardia syndrome
Author(s) -
Sammi Wong,
Sara Hasan,
Christina Parducci,
Bernadette Ann Riley
Publication year - 2022
Publication title -
aims allergy and immunology
Language(s) - English
Resource type - Journals
ISSN - 2575-615X
DOI - 10.3934/allergy.2022004
Subject(s) - postural orthostatic tachycardia syndrome , medicine , orthostatic intolerance , ehlers–danlos syndrome , orthostatic vital signs , connective tissue , dysautonomia , irritable bowel syndrome , mast cell , tachycardia , autonomic nervous system , gastroenterology , pathology , immunology , blood pressure , disease , heart rate
Ehlers-Danlos syndrome (EDS), mast cell activation syndrome, and postural orthostatic tachycardia syndrome are a triad of comorbid conditions that can occur simultaneously in many patients. Specifically, Ehlers-Danlos syndrome is a group of inherited connective tissue disorders that weakens the connective tissue and causes easy bruising. Mast cell activation syndrome (MCAS) is a condition in the connective tissue of vascularized organs that causes recurrent episodes of anaphylactic symptoms. The irregular activation of mast cells may contribute to immunological manifestations in EDS patients. Postural orthostatic tachycardia syndrome (POTS) is an autonomic nervous system disorder characterized by orthostatic intolerance. Review of the literature suggests an overlap of gastrointestinal (GI) symptoms such as nausea and abdominal pain, hernias, perforations, and more. Thus, this paper will delineate each condition's distinct gastrointestinal symptoms and explore similar gastrointestinal relationships among these conditions.