Active Compounds from Curcuma longa and Comparison of their Effectively Induced Apoptosis in MCF-7 Cell | Zendy

Ronny Lesmana | Zendy; Susianti Susianti | Zendy; Todia Pediatama | Zendy; Nova Sylviana | Zendy; Yuni Susanti Pratiwi | Zendy; Hanna Goenawan | Zendy; Unang Supratman | Zendy

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Active Compounds from Curcuma longa and Comparison of their Effectively Induced Apoptosis in MCF-7 Cell

Author(s) -

Ronny Lesmana,

Susianti Susianti,

Todia Pediatama,

Nova Sylviana,

Yuni Susanti Pratiwi,

Hanna Goenawan,

Unang Supratman

Publication year - 2021

Publication title -

pakistan journal of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 43

eISSN - 1812-5735

pISSN - 1028-8880

DOI - 10.3923/pjbs.2021.35.41

Subject(s) - curcuma , curcumin , mcf 7 , viability assay , mtt assay , chemistry , apoptosis , cancer cell , resazurin , pharmacology , traditional medicine , cancer , biochemistry , biology , human breast , medicine , genetics

The natural bioactive compounds of Curcuma longa, known as curcuminoids, has been shown to exerts anticancer effects to diverse cancer cell line in vitro, including breast cancer cell line. These curcuminoids consist of curcumin (Cur), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Furthermore, there has never been a study to compare the extent of antiproliferative and apoptotic modulation potential between Cur, DMC and BDMC in the breast cancer cell, until now. In the present study, we explore the efficacy among Cur, DMC and BDMC to alters MCF-7 cell viability, which might lead to apoptotic modulation.

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