In silico Identification of Peptide as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Treatment | Zendy

Shabrioor Imana | Zendy; Eka Gunarti Ningsih | Zendy; Usman Sumo Friend Tambunan | Zendy

Open Access

In silico Identification of Peptide as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Lung Cancer Treatment

Author(s) -

Shabrioor Imana,

Eka Gunarti Ningsih,

Usman Sumo Friend Tambunan

Publication year - 2020

Publication title -

pakistan journal of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 43

eISSN - 1812-5735

pISSN - 1028-8880

DOI - 10.3923/pjbs.2020.567.574

Subject(s) - epidermal growth factor receptor , pharmacophore , virtual screening , chemistry , in silico , peptide , egfr inhibitors , docking (animal) , adme , pubchem , biochemistry , cancer research , pharmacology , biology , receptor , medicine , gene , nursing , in vitro

Epidermal growth factor receptor (EGFR) is the biomarker for lung cancer in which the protein has the most active mutated genes in lung cancer patients. Peptides have pharmacological potential as drugs because of their bioactivity and accessibility. The research objective was to obtain peptide compounds drug candidates with good interaction and pharmacological properties that can act as an inhibitor for EGFR for lung cancer treatment by using in silico method.

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