Open AccessEffect of Papaya Leaves (Carica papaya L.) Extract on Immune Response (TLR-7, TLR-9) and Inflammation (COX-2) in Rats Induces DMBA (7,12-Dimethylbenz[a]antrasen)
Author(s) -
Fatma Zuhrotun N,
Mary Astuti,
Sofia Mubarika H,
Agnes Murdiati
Publication year - 2020
Publication title -
pakistan journal of biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.268
H-Index - 43
eISSN - 1812-5735
pISSN - 1028-8880
DOI - 10.3923/pjbs.2020.1450.1455
Subject(s) - immune system , inflammation , dmba , carica , pharmacology , cyclooxygenase , medicine , immunology , cancer , chemistry , traditional medicine , biology , enzyme , biochemistry , carcinogenesis , botany
TLR is known to regulate the immune system in cancer. TLR-7 and TLR-9 can enhance the antitumor immune system in many types of solid tumors. Cyclooxygenase-2 (COX-2) is a biomarker of inflammation. This study aimed to investigate the effect of papaya leaves extract on immune response (TLR 7, TLR 9) and inflammation (COX-2) in rats induced DMBA.
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