Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats | Zendy

Asmaa Magdy Zaazaa | Zendy; Bosy A. Abd El-Motelp | Zendy; Nadia Noble-Daoud Aniss | Zendy

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Potential Protective Role of Rutin and Alpha-lipoic Acid Against Cisplatin-induced Nephrotoxicity in Rats

Author(s) -

Asmaa Magdy Zaazaa,

Bosy A. Abd El-Motelp,

Nadia Noble-Daoud Aniss

Publication year - 2019

Publication title -

pakistan journal of biological sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.268

H-Index - 43

eISSN - 1812-5735

pISSN - 1028-8880

DOI - 10.3923/pjbs.2019.361.371

Subject(s) - nephrotoxicity , cisplatin , pharmacology , malondialdehyde , rutin , glutathione , creatinine , oxidative stress , medicine , intraperitoneal injection , toxicity , alpha lipoic acid , antioxidant , glutathione reductase , endocrinology , chemistry , glutathione peroxidase , catalase , chemotherapy , biochemistry , enzyme

Cisplatin-induced nephrotoxicity is a serious complication that restricts its utilization in cancer treatment. Rutin and alpha-lipoic acid have antioxidant effectiveness, anti-inflammatory efficacy and prevent oxidative stress. Therefore, the current study planned to investigate the potential defensive impacts of rutin and alpha-lipoic acid on cisplatin-induced renal damage in rats.

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