Open AccessFlow cytometric analysis of platelet surface glycoproteins in the diagnosis of thirty-two Turkish patients with Glanzmann thrombasthenia: a multicenter experience
Author(s) -
Berkay Saraymen,
Sabahattin Muhtaroğlu,
Mustafa Yavuz Köker,
Nazan Sarper,
Emine Zengin,
Canan Albayrak,
Davut Albayrak,
Bülent Zülfikar,
Başak Koç Şenol,
Esma Bentli,
Semih Yılmaz,
Aysun Çetin,
Bülent Eser,
Mustafa Çetın
Publication year - 2021
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-2006-107
Subject(s) - medicine , thrombasthenia , platelet membrane glycoprotein , flow cytometry , platelet , glanzmann's thrombasthenia , population , turkish population , gastroenterology , immunology , pathology , genetics , genotype , biology , gene , platelet aggregation , environmental health
Glanzmann thrombasthenia (GT) is a rare autosomal recessively inherited bleeding disorder characterized by the quantitative (type 1 and type 2) or qualitative (type 3) deficiency in platelet membrane glycoprotein (GP) IIb/IIIa (CD41a/CD61) fibrinogen receptors. In type 1, 2, and 3, CD41a/CD61 expression is 5%, 5%–20% and above 20%, respectively. In this study, diagnosis of GT was confirmed and subgroups were identified in 32 Turkish patients by flow cytometry analysis.