Open AccessEffect of betulinic acid administration on TLR-9/NF-κB /IL-18 levels in experimental liver injury
Author(s) -
Eda Dokumacıoğlu,
Hatice İskender,
Kübra Asena Terim Kapakin,
Güler Yenice,
Behzat Mokthare,
İsmail Bolat,
A. Hayırlı
Publication year - 2021
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-2004-184
Subject(s) - medicine , malondialdehyde , betulinic acid , pharmacology , liver injury , triglyceride , acetaminophen , lipid peroxidation , antioxidant , interleukin , inflammation , biochemistry , cholesterol , oxidative stress , cytokine , chemistry , biology , genetics
Acetaminophen (APAP), used in the composition of thousands of preparations, is the most commonly used analgesic and antipyretic drug. The present study aimed to investigate the potential protective effects of the betulinic acid (BA) treatment through an APAP-induced hepatotoxicity rat model, using inflammatory, biochemical, and histopathological parameters.