Open AccessMUC1 and MUC5AC implication in Tunisian colorectal cancer patients
Author(s) -
Meriam Hazgui,
Marwa Weslati,
Rahma Boughriba,
Donia Ounissi,
Dhouha Bacha,
Saâdia Bouraoui
Publication year - 2021
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-2003-29
Subject(s) - medicine , colorectal cancer , muc1 , mucin , immunohistochemistry , oncology , carcinogenesis , cancer , metastasis , biomarker , survival analysis , proportional hazards model , pathology , cancer research , gastroenterology , biology , biochemistry
Mucins, such as MUC1 and MUC5AC, are known for their protective and moisturizing role in intestinal epithelium. Their expression is tightly controlled given their essential role in normal tissue homeostasis, whereas their deregulation leads to chronic inflammation, and even cancer. This study aimed to assess the expression profiles of MUC1 and MUC5AC and their implications in colorectal carcinogenesis.