Open AccessNeuropeptide Y1 receptor antagonist but not neuropeptide Y itself increased bone mineral density when locally injected with hyaluronic acid in male Wistar rats
Author(s) -
Muhammer Özgür Çevik,
Petek Korkusuz,
Feza Korkusuz
Publication year - 2020
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-2001-268
Subject(s) - neuropeptide y receptor , bone mineral , medicine , endocrinology , antagonist , masson's trichrome stain , receptor antagonist , h&e stain , cortical bone , bone remodeling , quantitative computed tomography , neuropeptide , tibia , anatomy , receptor , immunohistochemistry , osteoporosis
The nervous system controls bone mass via both the central (CNS) and the peripheral (PNS) nervous systems. Intriguingly, neuropeptide Y (NPY) signaling occurs in both. Less is known on how the PNS stimulated NPY signaling controls bone metabolism. The objective of this study was to evaluate whether NPY or NPY1 receptor antagonist changes local bone mineral density (BMD) when injected into a Wistar rat tibia.