Open AccessColchicine intolerance in FMF patients and primary obstacles for optimal dosing
Author(s) -
Hasan Satış,
Berkan Armağan,
Erdal Bodakçı,
Nuh Ataş,
Alper Sarı,
Nazife Şule Yaşar Bilge,
Dilek Yapar,
Reyhan Bilici Salman,
G. K. Yardimci,
Hakan Babaoğlu,
Levent Kılıç,
Berna Göker,
Şeminur Haznedaroğlu,
Timuçin Kaşifoğlu,
Umut Kalyoncu,
Abdurrahman Tufan
Publication year - 2020
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-2001-261
Subject(s) - medicine , colchicine , familial mediterranean fever , discontinuation , dosing , leukopenia , diarrhea , toxicity , gastroenterology , liver disease , disease
Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation.