Open AccessBaicalein Nanofiber Scaffold Containing Hyaluronic Acid and Polyvinyl Alcohol: Preparation and Evaluation
Author(s) -
Kamel Bachımam,
Ezgi Emül,
Necdet Sağlam
Publication year - 2020
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-2001-123
Subject(s) - nanofiber , baicalein , polyvinyl alcohol , electrospinning , scaffold , biomedical engineering , scanning electron microscope , polymer , materials science , bone tissue , fourier transform infrared spectroscopy , medicine , chemical engineering , nanotechnology , composite material , engineering , pharmacology
Background/aim Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue. Materials and methods Electrospinning method was used in order to produce nanofibers from different kinds of polymers; Hyaluronic acid (HA), Polyethylene oxide (PEO) and Polyvinyl alcohol (PVA) blended with different concentrations of herbal antibiotic and anti cancer flavonoid molecules called Baicalein (BE). The morphological and chemical structures of scaffold samples were studied using Scanning Electron Microscope (SEM), Fourier Transform Infrared-spectroscopy (FT-IR) and Surface-enhanced Raman spectroscopy (SERS) Analysis. Results The results showed production of homogenous nanofibers-based scaffold (diameter between 80 nm and 470 nm) that contains the polymers used in the spinning process and the entrapped Baicalein molecules within the nanofiber structure. Conclusion It was concluded that successful formation of bone tissue mimicking scaffold can be achieved by using Electrospinning method that produces nonwoven nanofibers and at the same time can hold functional anticancer agent such as Baicalein, which may allow using these types of scaffold in bone cancer treatment procedures.