Open AccessSurface enhanced Raman spectroscopy as a novel tool for rapid quantification of heroin and metabolites in saliva
Author(s) -
Ramazan Akçan,
Mahmut Şerif Yıldırım,
Hasan İlhan,
Burcu Güven,
Uğur Tamer,
Necdet Sağlam
Publication year - 2020
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1912-196
Subject(s) - surface enhanced raman spectroscopy , saliva , heroin , raman spectroscopy , drug detection , opiate , colloidal gold , silver nanoparticle , chromatography , raman scattering , medicine , nanoparticle , nanotechnology , materials science , drug , chemistry , pharmacology , optics , physics , receptor
Heroin can be detected and quantified by certain analytical methods, however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy (SERS) rises as a possible alternative tool with its widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites, which are unfortunately controversial. In this study, we compared five different surfaces in order to find out more efficient Raman-active substrate for opiate detection and rapid quantification of heroin and its metabolites in saliva.