Open AccessEvaluation of the effects of β1-selective beta-blockers on bone mineral density and fracture risk in postmenopausal women
Author(s) -
Betül Yavuz Keleş,
Meltem Vural,
Burcu Önder,
Kadriye Öneş
Publication year - 2020
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1909-187
Subject(s) - medicine , frax , bone mineral , osteoporosis , postmenopausal women , hip fracture , fragility fracture , osteoporotic fracture
Background/aim β1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of β1-selective BBs on bone mineral density (BMD) and fracture risk. Materials and methods This study included postmenopausal women who used β1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX). Results A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were significantly higher in BB group than control group (P = 0.015 and P = 0.025, respectively). Moreover, T-scores of lumbar and femur total were significantly higher in the BB group. Two patients in BB and 6 patients in control group had previous fragility fracture. No statistically significant intergroup difference was noted regarding FRAX.Conclusion Based on our results, β1-selective BB usage was associated with higher BMD at the lumbar region in postmenopausal women.