Open AccessInterleukin 12B mRNA level and rs3212227 genotyping in peripheral blood mononuclear cells of inflammatory bowel disease patients
Author(s) -
Hamid Asadzadeh Aghdaei,
Elnaz Emami,
Mahyar Nourian,
Vahid Chaleshi,
Peyman Tarban,
Hedieh Balaii,
Pedram Azimzadeh,
Shiva Irani,
Shabnam Shahrokh,
Mohammad RostamiNejad,
Mohammad Reza Zali
Publication year - 2018
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1711-136
Subject(s) - single nucleotide polymorphism , medicine , peripheral blood mononuclear cell , genotyping , genotype , inflammatory bowel disease , immunology , snp genotyping , snp , immune system , interleukin , gene expression , gene , gastroenterology , disease , genetics , cytokine , biology , in vitro
Inflammatory bowel disease (IBD) is a multifactorial disorder. Single nucleotide polymorphisms (SNPs) in the IL-12 gene, which are the main factors to regulate the immune reaction, play an important role in the production of IL-12 molecules. The aim of this study was to evaluate the correlation between the SNP on position +1188 of the 3 ′ UTR region of the IL-12 p40 subunit gene and expression of the IL-12 p40 gene.