Open AccessDysregulation of the DKK1 gene in pediatric B-cell acute lymphoblastic leukemia
Author(s) -
Sinem Fırtına,
Özden Hatırnaz Ng,
Yücel Erbilgin,
Uğur Özbek,
Müge Sayitoğlu
Publication year - 2017
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1507-106
Subject(s) - dkk1 , wnt signaling pathway , lrp5 , lrp6 , methylation , cancer research , dna methylation , epigenetics , bisulfite sequencing , gene silencing , leukemia , microbiology and biotechnology , frizzled , medicine , gene , biology , gene expression , genetics
The canonical Wingless-type (WNT) pathway is involved in normal hematopoietic cell development and deregulated WNT signaling is implicated in the development of hematological malignancies. Dickkopf 1 (DKK1) acts as a modulator of the β-catenin regulated canonical pathway. Activation of DKK1 leads to apoptosis and growth suppression, whereas silencing by promoter hypermethylation results in abnormal WNT activation. The secreted inhibitor Dickkopf can antagonize WNT signaling by competitively binding to low density lipoprotein receptors (LRPs) 5 and 6.