Open AccessBTLA (C272) expression on CD4+ T cells in Behçet patients
Author(s) -
Fulya İlhan,
Nesrin Demir,
Tamer Demır,
Ahmet Gödekmerdan
Publication year - 2012
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1105-32
Subject(s) - btla , medicine , immunology , cd3 , t cell , immune system , t lymphocyte , behcet's disease , etiology , cd28 , lymphocyte , disease , cd8
doi:10.3906/sag-1105-32 BTLA (C272) expression on CD4+ T cells in Behçet patients* Nafi ye Fulya İLHAN1, Nesrin DEMİR1, Tamer DEMİR2, Ahmet GÖDEKMERDAN1 Aim: To investigate the peripheral blood levels of B and T lymphocyte attenuator (BTLA/CD272) on T cells and its role in Behçet disease (BD), and to defi ne the role of inhibitory receptors on BD. Materials and methods: Included in this study were 25 patients with BD and 20 healthy control subjects, matched for age and sex. Results: CD4+CD272+ (P < 0.001) and CD3+CD272+ (P < 0.001) T cell levels were signifi cantly higher in BD patients (active and remission) compared to the healthy controls. However, there was no diff erence between the active patients and those in remission in terms of CD4+CD272+ T cells, while CD3+CD272+ T cell levels were signifi cantly higher in active-phase BD patients compared to patients in the remission phase (P < 0.05). Conclusion: Further functional studies could be implemented to investigate the eff ectiveness of the present research parameter in the diagnosis or follow-up of certain diseases similar to BD and with obscure etiology, as well as its contribution to immune dysregulation of BD. BTLA can additionally modulate T cell response in BD on diff erent infl ammatory areas and it can be upregulated in BD because of T cell activation. Th e results of the present study indicate that BTLA expression on CD4+ Th (T helper) cells might play a limiting role on the infl ammation at peripheral sites or organs in BD