Effects of phenolic acids on gastrointestinal smooth muscle complications in streptozotocine-induced diabetic rats

doi:10.3906/sag-1101-1455 Eff ects of phenolic acids on gastrointestinal smooth muscle complications in streptozotocine-induced diabetic rats Nurcan BEKTAŞ, Yusuf ÖZTÜRK Aim: To identify the eff ects of antioxidants on gastrointestinal smooth muscle complications in 6-week streptozotocine (STZ)-induced diabetic rats. Materials and methods: Th e following steps were carried out: 1. Th ree weeks aft er STZ injection, saline and 10 mg/kg p-OH benzoic, protocatechic, and gallic acids were separately administered to the rat groups every day for 3 weeks. 2. Th e responses of the fundus and ileum to agonists were recorded using isolated organ bath experiments. Results: Diabetic smooth muscle complications developed in the diabetic rats. Th e responses of the ileum to acetylcholine increased whereas the responses of the fundus to serotonine decreased in the diabetic rats. Th e test drugs inhibited and promoted but did not aff ect the smooth muscle complications in the diabetic rats, and sometimes they aff ected the smooth muscle activity, which did not change with diabetes. Conclusion: Th e antioxidants used elicited pro-oxidant activation and/or exhibited eff ects independent of diabetic complications of gastrointestinal smooth muscles in the experimental conditions applied. Key words: Diabetes mellitus, gastrointestinal tract complication, p-OH benzoic acid, protocatechic acid, gallic acid Fenolik asitlerin streptozotosin ile diyabet oluşturulmuş sıçanlarda gelişen gastrointestinal düz kas komplikasyonları üzerine etkileri Amaç: Bu çalışma, antioksidanların streptozotosin (STZ) ile diyabet oluşturulmuş altı haft alık diyabetik sıçanlarda gelişen gastrointestinal düz kas komplikasyonları üzerine etkilerini incelemeyi amaçlamıştır