Effects of two different doses of acetylsalicylic acid on serum nitric oxide, asymmetric dimethylarginine, and homocysteine levels in healthy volunteers*

doi:10.3906/sag-1012-1322 Eff ects of two diff erent doses of acetylsalicylic acid on serum nitric oxide, asymmetric dimethylarginine, and homocysteine levels in healthy volunteers* İdris MEHMETOĞLU, Sevil KURBAN Aim: To examine the eff ects of ASA on serum nitric oxide (NO), asymmetric dimethylarginine (ADMA), and homocysteine levels in healthy volunteers. Materials and methods: Totally, 26 apparently healthy volunteers were enrolled in the study. Of the participants, 13 (5F, 8M) received 100 mg ofASA daily and 13 (5F, 8M) received 150 mg of ASA daily for 2 months. Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months aft er ASA treatment Serum NO, ADMA, and homocysteine levels were measured before and 1 and 2 months aft er ASA treatment. Results: ADMA levels of the group receiving 150 mg of ASA were signifi cantly reduced aft er 2 months of treatment (P < 0.05). NO levels of both groups were slightly but not signifi cantly increased and homocysteine levels of both groups were slightly reduced aft er ASA treatment compared to the baseline values. Conclusion: Our fi ndings indicate that ASA treatment reduces ADMA levels dose and time dependently, a benefi cia