Open AccessPrevalence of latent prostate cancer and prostatic intraepithelial neoplasia in İstanbul, Turkey: an autopsy study
Author(s) -
Nusret Akpolat,
Yalçın Büyük,
İbrahim Üzün,
İlhan Geçit,
Gülay Kurnaz
Publication year - 2012
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1008-1052
Subject(s) - medicine , high grade prostatic intraepithelial neoplasia , intraepithelial neoplasia , prostate cancer , turkish population , prostate , population , gynecology , cancer , urology , oncology , gastroenterology , genotype , biochemistry , chemistry , environmental health , gene
doi:10.3906/sag-1008-1052 Prevalence of latent prostate cancer and prostatic intraepithelial neoplasia in İstanbul, Turkey: an autopsy study Nusret AKPOLAT1, Yalçın BÜYÜK2, İbrahim UZUN2, İlhan GEÇİT3, Gülay KURNAZ2 Aim: To investigate the frequency of latent prostatic carcinoma (PCa) and prostatic intraepithelial neoplasia (PIN) in the Turkish population. Materials and methods: PCa and PIN were evaluated in 116 male autopsy cases in which the cause of death was nontumoral. All patients were Turkish, living in İstanbul, and aged 40-79 years. Results: Th e prevalence of PCa was 19.8 % and the decade rates (decades 5-8) were 9.5%, 12.5%, 18.8%, and 37%, respectively (P < 0.011). Th e rates of high-grade prostatic intraepithelial neoplasia (HGPIN) were 33.3%, 31.3%, 56.3%, and 25.9 % for decades 5-8, respectively (P> 0.05). A total of 68.4 % of PCa cases were HGPIN. Th ere was a statistically signifi cant correlation among HGPIN, PCa, and Gleason scores (P < 0.002). Conclusion: Th e prevalence of latent PCa in the Turkish population is very high (19.7%). In order to determine latent PCa cases, males over 40 years of age must be screened more strictly