The effect of omega-3 fatty acid supplementation on plasma orexin A, plasma fatty acids, and anthropometric measurements in patients with narcolepsy

doi:10.3906/sag-1003-705 Th e eff ect of omega-3 fatty acid supplementation on plasma orexin A, plasma fatty acids, and anthropometric measurements in patients with narcolepsy Makbule GEZMEN KARADAĞ1, Meral AKSOY2 Aim: To determine the eff ect of omega-3 (n-3) fatty acid supplementation on plasma orexin A, plasma fatty acids, and anthropometric measurements in patients with narcolepsy. Materials and methods: Th e study was performed on 17 males with narcolepsy and 14 healthy males between the ages of 21-55. An n-3 fatty acid supplement of 1.4 g/day was administered to the groups for 2 months. Th e anthropometric measurements of the individuals were taken at the onset and the end of trial, and orexin, fatty acids, and other biochemical parameters in the plasma were analyzed. Results: While there was no statistically signifi cant change in anthropometric measurements or the other body composition values of the patient group (P> 0.05), there was a statistically signifi cant increase in the body weight, body mass index, waist-to-hip ratio, and body fat mass values (kg, %) of the control group (P < 0.05). Th ere was no diff erence in the levels of plasma orexin A of the patients within or between groups in the pre- and poststudy measurements (P> 0.05). Th e poststudy plasma serotonin levels of the patients were lower and plasma insulin levels were higher than in the initial study (P < 0.05). Th ere was a correlation between the plasma orexin A levels and plasma n-3 fatty acids in individuals in the control group at the onset of the study (P < 0.05). Depending on the increase of the fatty acids aft er the n-3 supplementation, a correlation between plasma orexin A levels and some fatty acids was observed (P < 0.05). Conclusion: Th e data demonstrated that supplementation of n-3 fatty acid did not enhance the plasma orexin A level but did aff ect some other biochemical parameters