Open AccessThe levels of nitric oxide and metabolites in Behçet's disease
Author(s) -
İbrahim Kökçam,
Selma Bakar Dertlıoğlu
Publication year - 2011
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1002-627
Subject(s) - medicine , nitric oxide , pathogenesis , endothelial dysfunction , asymmetric dimethylarginine , behcet's disease , mucocutaneous zone , gastroenterology , disease , arginine , endocrinology , biochemistry , chemistry , amino acid
doi:10.3906/sag-1002-627 Th e levels of nitric oxide and metabolites in Behçet’s disease İbrahim KÖKÇAM, Selma BAKAR DERTLİOĞLU Aim: Endothelial damage and dysfunction are held responsible for the etiopathogenesis of Behçet’s disease (BD). In the present study, we aimed to investigate the relationship of BD with nitric oxide (NO), asymmetrical dimethylarginine (ADMA), symmetrical dimethylarginine (SDMA) and L-arginine levels, which are known to play a role in the pathogenesis of vasculitis. Materials and methods: Sixty patients enrolled in the study were allocated to groups as follows: active/inactive patient groups; the patient group with active/inactive vessel involvement, and mucocutaneous patient group without vessel involvement. Results: NO, SDMA, ADMA levels of the active patients and SDMA and ADMA levels of the inactive patients were found to be signifi cantly higher than those of the healthy controls. SMDA and ADMA levels in the group with active vessel involvement; NO, SDMA, ADMA, and L-arginine levels in the group with inactive vessel involvement; and, NO, SDMA, and ADMA levels of the mucocutaneous group were signifi cantly higher than those of the healthy controls. However we detected no statistically signifi cant diff erence among the patient groups