Open AccessManagement of thyroid cancer associated with elevated serum thyroglobulin and negative radioiodine scanning
Author(s) -
Suat Çağlayan,
Muammer Urhan,
Onur Sıldıroğlu,
Yavuz Kurt,
M Onde,
Yavuz Narịn
Publication year - 2009
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-0811-21
Subject(s) - medicine , thyroid carcinoma , thyroid cancer , thyroglobulin , thyroid , radiology , carcinoma , papillary thyroid cancer , cancer , pathological , pathology , gastroenterology , nuclear medicine
doi:10.3906/sag-0811-21 Management of thyroid cancer associated with elevated serum thyroglobulin and negative radioiodine scanning Aim: Differentiated thyroid carcinoma has a favorable prognosis, even in the presence of distant metastases, if the tumor cells are able to concentrate radioiodine. Nonetheless, up to 30 % of thyroid cancer patients with elevated serum thyroglobulin (Tg) and negative radioiodine whole-body scan findings represent a diagnostic dilemma. In this study we assessed the diagnostic contribution of anatomical and functional imaging procedures, including US of the thyroid bed and neck, CT scanning of the chest and mediastinum, and FDG PET whole-body scanning, in iodine-negative/Tg-positive thyroid cancer patients. Materials and methods: The study included 28 patients (20 female, 8 male; age range: 21-85 years; mean age: 56 years) with a proven diagnosis of thyroid carcinoma. The pathological diagnosis was papillary carcinoma in 26 patients, and Hurtle-cell carcinoma and poorly differentiated thyroid carcinoma, respectively, in the 2 remaining patients. All patients had undergone thyroid surgery an