Open AccessCytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
Author(s) -
Metin Yıldırım,
Mehmet Erşatır,
Badel Arslan,
Elife Sultan Giray
Publication year - 2021
Publication title -
turkish journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.239
H-Index - 46
eISSN - 1303-6130
pISSN - 1300-0527
DOI - 10.3906/kim-2008-56
Subject(s) - chemistry , coumarin , malononitrile , salicylaldehyde , ethyl acetoacetate , apoptosis , proton nmr , cytotoxic t cell , cell culture , combinatorial chemistry , organic chemistry , stereochemistry , biochemistry , schiff base , in vitro , biology , genetics , catalysis
3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.