Open AccessHost variations in SARS-CoV-2 infection
Author(s) -
Doruk ALTIOK,
Elif Zeynep SAVCI,
Büşra ÖZKARA,
Kamil ALKAN,
Dilara Sultan NAMDAR,
Gizem Tuncer,
Buğrahan Regaip KILINÇ,
Evren SUİÇMEZ,
G. Ozan Çetin,
Sinan Ünal,
Beyza Dönmüş,
Zeynep Yağmur KARAGÜLLEOĞLU,
Dilruba Beyza Uncuoglu,
Cansu Tekeli,
Ayşegül Mendi,
V. Umut Bengi,
Güldane Cengiz Seval,
Pelin Kilic,
Evrim Güneş Altuntaş,
Devrim Demir Dora
Publication year - 2021
Publication title -
turkish journal of biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 38
eISSN - 1303-6092
pISSN - 1300-0152
DOI - 10.3906/biy-2104-67
Subject(s) - biology , covid-19 , coronavirus , disease , host (biology) , pathogenesis , host factors , virology , race (biology) , immunology , betacoronavirus , pathogen , epidemiology , virus , genetics , infectious disease (medical specialty) , medicine , outbreak , pathology , botany
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.