Open AccessE-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells
Author(s) -
Esra Aydemir Çoban,
Didem Tecimel,
Ezgi Kaşıkcı,
Ömer Faruk Bayrak,
Fikrettin Şahın
Publication year - 2020
Publication title -
turkish journal of biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.323
H-Index - 38
eISSN - 1303-6092
pISSN - 1300-0152
DOI - 10.3906/biy-1912-60
Subject(s) - cadherin , cdh1 , pancreatic cancer , biology , cancer research , adenocarcinoma , cancer cell , cancer , cell , medicine , genetics
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.