Open AccessAppropriate Use of Glycopeptide Antibiotics and Therapeutic Drug Monitoring for Invasive Infections
Author(s) -
Si-Ho Kim,
Lee SooYoun,
Cheol-In Kang
Publication year - 2021
Publication title -
the korean journal of medicine
Language(s) - English
Resource type - Journals
eISSN - 2289-0769
pISSN - 1738-9364
DOI - 10.3904/kjm.2021.96.6.463
Subject(s) - teicoplanin , glycopeptide , vancomycin , antibiotics , therapeutic drug monitoring , glycopeptide antibiotic , pharmacokinetics , pharmacodynamics , medicine , minimum inhibitory concentration , drug , pharmacology , microbiology and biotechnology , biology , staphylococcus aureus , bacteria , genetics
Vancomycin and teicoplanin are representative glycopeptide antibiotics with activities against gram-positive cocci. The area under the drug concentration–time curve (AUC)/minimal inhibitory concentration (MIC) has been extensively used as an indicator of the bacteriological response to glycopeptide antibiotics, and the trough concentration has been used as a surrogate marker for the AUC/MIC. However, the guidelines for therapeutic drug monitoring (TDM) are being revised in accordance with increasing pharmacokinetic understanding of glycopeptide antibiotics. This review describes the pharmacokinetic/pharmacodynamic characteristics of glycopeptide antibiotics and discusses their optimal use with appropriate TDM.