Open AccessEpidermal Neurite Density in Skin Biopsies From Patients With Juvenile Fibromyalgia
Author(s) -
Alexis Boneparth,
Shan Chen,
Daniel B. Horton,
Lakshmi N. Moorthy,
I.E. Farquhar,
Heather Downs,
Hang Lee,
Anne Louise Oaklander
Publication year - 2020
Publication title -
the journal of rheumatology/journal of rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.577
H-Index - 178
eISSN - 1499-2752
pISSN - 0315-162X
DOI - 10.3899/jrheum.200378
Subject(s) - medicine , fibromyalgia , dysautonomia , skin biopsy , biopsy , rheumatology , juvenile , physical therapy , disease , biology , genetics
Fibromyalgia (FM) is defined by idiopathic, chronic, widespread musculoskeletal pain. In adults with FM, a metaanalysis of lower-leg skin biopsy demonstrated 45% pooled prevalence of abnormally low epidermal neurite density (END). END < 5th centile of the normal distribution is the consensus diagnostic threshold for small-fiber neuropathy. However, the clinical significance of END findings in FM is unknown. Here, we examine the prevalence of small-fiber pathology in juvenile FM, which has not been studied previously.