Open AccessEndothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis
Author(s) -
Takayuki Kishi,
Jonathan Chipman,
Melvina Evereklian,
Khanh Nghiem,
Maryalice StetlerStevenson,
Margaret E. Rick,
Michael Centola,
Frederick W. Miller,
Lisa G. Rider
Publication year - 2019
Publication title -
the journal of rheumatology/journal of rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.577
H-Index - 178
eISSN - 1499-2752
pISSN - 0315-162X
DOI - 10.3899/jrheum.181275
Subject(s) - medicine , thrombomodulin , von willebrand factor , juvenile dermatomyositis , endothelial activation , endothelium , antigen , immunology , endothelial dysfunction , endocrinology , pathology , platelet , dermatomyositis , thrombin
Circulating endothelial cells (CEC), von Willebrand factor (vWF) antigen, P-selectin, and thrombomodulin are released from damaged endothelium, while decreases in circulating endothelial progenitor cells (CEPC) have been associated with poor vascular outcomes. We examined these markers in the peripheral blood of patients with juvenile dermatomyositis (JDM) and their correlations with disease assessments.