Open AccessThe mutant isocitrate dehydrogenase 1 product, 2‑hydroxyglutarate, activates MutT homolog 1 in glioma cells via the augmentation of reactive oxygen species levels
Author(s) -
Bharathan Bhavya,
Chellapan Anand,
Madhusoodanan Urulangodi,
K. Sreelakshmi,
A. N. Deepti,
Girish Me,
Krishnakumar Kesavapisharady,
H. V. Easwer,
Srinivas Gopala
Publication year - 2022
Publication title -
world academy of sciences journal
Language(s) - English
Resource type - Journals
eISSN - 2632-2919
pISSN - 2632-2900
DOI - 10.3892/wasj.2022.174
Subject(s) - isocitrate dehydrogenase , reactive oxygen species , mutant , idh1 , glioma , downregulation and upregulation , chemistry , wild type , enzyme , cancer cell , biochemistry , cancer research , microbiology and biotechnology , biology , cancer , gene , genetics