Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients | Zendy

Soňa Vodenková | Zendy; Michal Kroupa | Zendy; Z Polívková | Zendy; Ľudovít Mušák | Zendy; Miloslav Ambruš | Zendy; Michaela Schneiderová | Zendy; Renata Koževnikovová | Zendy; Ľudmila Vodičková | Zendy; Sivaramakrishna Rachakonda | Zendy; Kari Hemminki | Zendy; Rajiv Kumar | Zendy; Pavel Vodiĉka | Zendy

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Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

Author(s) -

Soňa Vodenková,

Michal Kroupa,

Z Polívková,

Ľudovít Mušák,

Miloslav Ambruš,

Michaela Schneiderová,

Renata Koževnikovová,

Ľudmila Vodičková,

Sivaramakrishna Rachakonda,

Kari Hemminki,

Rajiv Kumar,

Pavel Vodiĉka

Publication year - 2020

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2020.7774

Subject(s) - telomere , chromosome instability , breast cancer , colorectal cancer , cancer , molecular medicine , lung cancer , oncology , medicine , oncogene , genome instability , peripheral blood lymphocyte , lymphocyte , biology , pathology , dna damage , cell cycle , chromosome , genetics , dna , gene

Accumulation of non‑specific structural chromosomal aberrations (CAs) and telomere shortening contribute to genome instability, which constitutes as one of the hallmarks of cancer. CAs arise due to direct DNA damage or telomere shortening. CAs in peripheral blood lymphocytes (PBL), which are considered to be markers of exposure, have been previously reported to serve a role in the pathophysiology and progression of cancer through mechanisms that are poorly understood. In addition, the prognostic relevance of telomere length (TL) in patients with cancer remains to be elucidated. In the present study, CAs and TL in PBL isolated from patients with newly diagnosed cancer (151 breast, 96 colorectal, 90 lung) and 335 cancer‑free control individuals were investigated. These results were then correlated with clinicopathological factors and follow‑up data. The accumulation of CAs in PBL was observed with increased susceptibility to breast and lung cancer (P<0.0001), while individuals with longer TL were found to be at a higher risk of breast cancer (P<0.0001). Increased chromatid‑type aberrations were also revealed to be associated with lower overall survival of patients with breast and colorectal cancers using a multivariate model. Compared with control individuals, no association was observed between TL and CAs or age in patients with cancer. In conclusion, the present study demonstrates the association between CAs/TL in PBL and the susceptibility, prognosis and survival of patients with breast, colorectal and lung cancer.

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