MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer | Zendy

Yasu Jiang | Zendy; Yunhui Cai | Zendy; Weiwei Shao | Zendy; Li Feng | Zendy; Zongyu Guan | Zendy; Yi Zhou | Zendy; Chong Tang | Zendy; Shichun Feng | Zendy

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MicroRNA‑144 suppresses aggressive phenotypes of tumor cells by targeting ANO1 in colorectal cancer

Author(s) -

Yasu Jiang,

Yunhui Cai,

Weiwei Shao,

Li Feng,

Zongyu Guan,

Yi Zhou,

Chong Tang,

Shichun Feng

Publication year - 2019

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2019.7025

Subject(s) - downregulation and upregulation , oncogene , cancer research , microrna , colorectal cancer , cancer , cell cycle , molecular medicine , epidermal growth factor receptor , metastasis , tumor progression , biology , medicine , biochemistry , gene

The aim of the present study was to research the mechanism of action of microRNA‑144 (miR‑144) in colorectal cancer (CRC) and its role in tumor progression. It was demonstrated that miR‑144 was downregulated and anoctamin 1 (ANO1) expression was upregulated in CRC. The expression of ANO1 was negatively associated with that of miR‑144 in CRC. The present study indicated that upregulated expression of ANO1 was associated with poor differentiation and advanced tumor‑node‑metastasis stage. It was verified that upregulation of ANO1 expression activated the epidermal growth factor receptor/extracellular signal‑regulated kinase signaling pathway. It was also demonstrated that miR‑144 exerts strong tumor‑inhibiting effects by targeting ANO1. Therefore, miR‑144 may have potential as a prognostic marker or therapeutic target for CRC.

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