Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR‑206 | Zendy

Yuanhong Chang | Zendy; Jie Zhang | Zendy; Cancan Zhou | Zendy; Guanglin Qiu | Zendy; Guanghui Wang | Zendy; Shufeng Wang | Zendy; Xin-Ming Chang | Zendy; Xuqi Li | Zendy; Lin Fan | Zendy

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Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR‑206

Author(s) -

Yuanhong Chang,

Jie Zhang,

Cancan Zhou,

Guanglin Qiu,

Guanghui Wang,

Shufeng Wang,

Xin-Ming Chang,

Xuqi Li,

Lin Fan

Publication year - 2018

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2018.6752

Subject(s) - oncogene , hepatocellular carcinoma , long non coding rna , cell cycle , cancer research , biology , molecular medicine , rna , microrna , genetics , cancer , gene

Recently, long non-coding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) has been recognized to function as an oncogene in several human tumors, and FOXD2‑AS1 dysregulation has been closely associated with carcinogenesis and tumor progression. Nevertheless, the correlation between the aberrant expression of FOXD2‑AS1 and the prognosis of hepatocellular carcinoma (HCC) has not yet been elucidated. In the present study, FOXD2‑AS1 was found to be overexpressed in HCC tissues, and FOXD2‑AS1 overexpression resulted in significantly shortened patient survival. FOXD2‑AS1 overexpression enhanced the viability and metastasis of HCC cells in vitro and in vivo, as revealed by MTT, wound healing and cell migration assays. In addition, mechanistic studies revealed that FOXD2‑AS1 upregulated the expression of the miR‑206 target gene annexin A2 (ANXA2) by acting as a miR‑206 sponge. In summary, FOXD2‑AS1 was concluded to function as an oncogene in HCC and to upregulate ANXA2 expression in part by 'sponging' miR‑206.

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