LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion | Zendy

Yuanxia Li | Zendy; Xiaolei Wan | Zendy; Wei Ye | Zendy; Xiuwen Liu | Zendy; Wensheng Lai | Zendy; Liuping Zhang | Zendy; Jie Jin | Zendy; Chaoyang Wu | Zendy; Qixiang Shao | Zendy; Genbao Shao | Zendy; Qiong Lin | Zendy

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LSD1-mediated epigenetic modification contributes to ovarian cancer cell migration and invasion

Author(s) -

Yuanxia Li,

Xiaolei Wan,

Wei Ye,

Xiuwen Liu,

Wensheng Lai,

Liuping Zhang,

Jie Jin,

Chaoyang Wu,

Qixiang Shao,

Genbao Shao,

Qiong Lin

Publication year - 2016

Publication title -

oncology reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.094

H-Index - 96

eISSN - 1791-2431

pISSN - 1021-335X

DOI - 10.3892/or.2016.4729

Subject(s) - epithelial–mesenchymal transition , ovarian cancer , cell migration , demethylase , cancer research , biology , vimentin , oncogene , epigenetics , metastasis , cancer , cadherin , cancer cell , cell , cell cycle , immunology , genetics , gene , immunohistochemistry

Lysine-specific demethylase 1 (LSD1) has been implicated in the process of tumor progression at various steps, but its role in epithelial-messenchymal transition (EMT) and the migration of ovarian cancer cells remains obscure. In this study, we demonstrated the effect of LSD1 on ovarian cancer cell migration and the regulatory role of LSD1 in the expression of EMT markers. Inhibition of LSD1 expression impaired the migration and invasion of HO8910 ovarian cancer cells. In contrast, overexpression of LSD1 enhanced the cell migration and invasion of HO8910 cells. Mechanistic analyses showed that LSD1 promoted cell migration through induction of N-cadherin, vimentin, MMP-2 and inhibition of E-cadherin. Furthermore, LSD1 interacted with the promoter of E-cadherin and demethylated histone H3 lysine 4 (H3K4) at this region, downregulated E-cadherin expression, and consequently enhanced ovarian cancer cell migration. These data indicate that LSD1 acts as an epigenetic regulator of EMT and contributes to the metastasis of ovarian cancer.

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