Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling | Zendy

Xiaoxuan Wang | Zendy; Yoshiyuki Yamamoto | Zendy; Mamiko Imanishi | Zendy; Xiaochen Zhang | Zendy; Masashi Sato | Zendy; Akinori Sugaya | Zendy; Mitsuaki Hirose | Zendy; Shinji Endo | Zendy; Yukikazu Natori | Zendy; Toshikazu Moriwaki | Zendy; Kenji Yamato | Zendy; Ichinosuke Hyodo | Zendy

Open Access

Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling

Author(s) -

Xiaoxuan Wang,

Yoshiyuki Yamamoto,

Mamiko Imanishi,

Xiaochen Zhang,

Masashi Sato,

Akinori Sugaya,

Mitsuaki Hirose,

Shinji Endo,

Yukikazu Natori,

Toshikazu Moriwaki,

Kenji Yamato,

Ichinosuke Hyodo

Publication year - 2021

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2021.12819

Subject(s) - trametinib , cancer research , mdm2 , mek inhibitor , oncogene , kinase , biology , kras , gene knockdown , transactivation , mapk/erk pathway , ubiquitin ligase , cell cycle , cancer cell , small interfering rna , apoptosis , chemistry , cancer , colorectal cancer , microbiology and biotechnology , cell culture , transfection , ubiquitin , transcription factor , biochemistry , gene , genetics

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research