Open AccessEnhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild‑type TP53 colon and gastric cancer cells with aberrant KRAS signaling
Author(s) -
Xiaoxuan Wang,
Yoshiyuki Yamamoto,
Mamiko Imanishi,
Xiaochen Zhang,
Masashi Sato,
Akinori Sugaya,
Masao Hirose,
Shunsuke Endo,
Yukikazu Natori,
Toshikazu Moriwaki,
Yamato Kikkawa,
Ichinosuke Hyodo
Publication year - 2021
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2021.12819
Subject(s) - trametinib , cancer research , mdm2 , mek inhibitor , oncogene , kinase , biology , kras , gene knockdown , transactivation , mapk/erk pathway , ubiquitin ligase , cell cycle , cancer cell , small interfering rna , apoptosis , chemistry , cancer , colorectal cancer , microbiology and biotechnology , cell culture , transfection , ubiquitin , transcription factor , biochemistry , gene , genetics