Open AccessRegulatory role of long non‑coding RNA UCA1 in signaling pathways and its clinical applications (Review)
Author(s) -
Zhaoping Liu,
Yanyan Wang,
Shunling Yuan,
Wen Feng,
Jing Liu,
Liheng Zou,
Ji Zhang
Publication year - 2021
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2021.12665
Subject(s) - wnt signaling pathway , biology , epigenetics , long non coding rna , cell cycle , oncogene , cancer research , chromatin , signal transduction , mapk/erk pathway , chromatin remodeling , pi3k/akt/mtor pathway , histone , biomarker , protein kinase b , regulation of gene expression , computational biology , gene , microbiology and biotechnology , rna , genetics
Long non-coding RNA metastasis-associated urothelial carcinoma associated 1 ( UCA1 ) plays a pivotal role in various human diseases. Its gene expression is regulated by several factors, including transcription factors, chromatin remodeling and epigenetic modification. UCA1 is involved in the regulation of the PI3K/AKT, Wnt/β-catenin, MAPK, NF-κB and JAK/STAT signaling pathways, affecting a series of cellular biological functions, such as cell proliferation, apoptosis, migration, invasion and tumor drug resistance. Furthermore, UCA1 is used as a novel potential biomarker for disease diagnosis and prognosis, as well as a target for clinical gene therapy. The present review systematically summarizes and elucidates the mechanisms of upstream transcriptional regulation of UCA1 , the regulatory role of UCA1 in multiple signaling pathways in the occurrence and development of several diseases, and its potential applications in clinical treatment.