Long non‑coding RNA RP11‑480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β‑catenin signaling pathway | Zendy

Li Zhang | Zendy; Yaqin Li | Zendy; Lina Sona | Zendy

Open Access

Long non‑coding RNA RP11‑480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β‑catenin signaling pathway

Author(s) -

Li Zhang,

Yaqin Li,

Lina Sona

Publication year - 2019

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2019.11120

Subject(s) - wnt signaling pathway , oncogene , epithelial–mesenchymal transition , cancer research , biology , cell cycle , gene knockdown , catenin , tumor progression , metastasis , cell growth , long non coding rna , beta catenin , cell migration , downregulation and upregulation , cancer , signal transduction , cell , microbiology and biotechnology , cell culture , gene , genetics

The long non-coding RNA (lncRNA), RP11-480I12.5 is one of the most dysregulated lncRNAs, which is believed to contribute to the progression of cervical carcinoma (CC); however, the exact function of RP11-480I12.5 in human CC remains unknown. The present study aimed to investigate the function and underlying molecular mechanism of RP11-480I12.5 in CC. First, reverse transcription-quantitative PCR was implemented in order to detect differences in the expression of RP11-480I12.5 between normal and CC tissues. The present study used in vitro analysis to establish RP11-480I12.5 stable knockdown and overexpressing cell lines, in order to investigate the function and potential molecular mechanism of RP11-480I12.5 in the progression of CC. RP11-480I12.5 was upregulated in CC tissue compared with normal tissue. Furthermore, RP11-480I12.5 was associated with clinical stage, tumor size and lymph node metastasis. RP11-480I12.5 promoted the proliferation, migration and invasion of CC cell lines. Subsequently, the present study investigated the association between RP11-480I12.5 and the epithelial-to-mesenchymal transition (EMT) and Wnt/β-catenin pathways. RP11-480I12.5 promoted EMT through the Wnt/β-catenin pathway. Overall, the results of the present study demonstrate that RP11-480I12.5 promotes cercical cancer cell migration, invasion and EMT through the Wnt/β-catenin pathway.

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