miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1 | Zendy

Zhe Jin | Zendy; Baoxing Jia | Zendy; Ludong Tan | Zendy; Yahui Liu | Zendy

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miR‑330‑3p suppresses liver cancer cell migration by targeting MAP2K1

Author(s) -

Zhe Jin,

Baoxing Jia,

Ludong Tan,

Yahui Liu

Publication year - 2019

Publication title -

oncology letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2019.10280

Subject(s) - oncogene , liver cancer , microrna , cancer , cancer research , biology , cell cycle , cancer cell , transfection , cell , molecular medicine , kinase , gene , microbiology and biotechnology , biochemistry , genetics

MicroRNAs, considered as a promising focus for the treatment of tumors, are key regulators of a large number of genes. The aim of the present study was to investigate the biological functions of microRNA (miR)-330-3p in liver cancer as it had been identified previously that miR-330-3p was deregulated in liver cancer. In order to identify the function of miR-330-3p in liver cancer, the expression of miR-330-3p was determined in liver cancer tissues and adjacent non-tumor tissues using reverse transcription-quantitative polymerase chain reaction analysis. To elucidate the function of miR-330-3p in liver cancer, miR-330-3p was overexpressed using mimic transfection. Cell migration was inhibited by miR-330-3p in liver cancer cells. The miRNA target prediction databases were used to identify potential target genes of miR-330-3p in liver cancer. The RNA level of mitogen-activated protein kinase kinase 1 (MAP2K1) was downregulated by miR-330-3p in liver cancer cells. In conclusion, miR-330-3p suppresses cell migration by targeting MAP2K1 in liver cancer cells.

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