Open AccessAnti‑inflammatory and antitumor action of hydrogen via reactive oxygen species (Review)
Author(s) -
Yang Ys,
Yue Zhu,
Xiaowei Xi
Publication year - 2018
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2018.9023
Subject(s) - reactive oxygen species , peroxynitrite , chemistry , antioxidant , oxidative stress , oxidative phosphorylation , apoptosis , peroxynitrous acid , hydroxyl radical , pharmacology , microbiology and biotechnology , biochemistry , cancer research , superoxide , biology , enzyme
Hydrogen (H 2 ) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic applications. H 2 can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or saline to produce H 2 water or H 2 -rich saline. H 2 selectively reduces oxidants of the detrimental reactive oxygen species (ROS), including hydroxyl radicals (·OH) and peroxynitrite (ONOO - ), which serve a causative role in the promotion of tumor cell proliferation, invasion and metastasis, but do not disturb metabolic oxidation-reduction reactions in cell signaling. Compared with traditional antioxidants, H 2 is a small molecule that can easily dissipate throughout the body and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H 2 may involve correction of the oxidative/anti-oxidative imbalance and suppression of inflammatory mediators. Therefore the present review will discuss the anti-inflammatory and anti-tumorigenic action of H 2 via ROS.