Open AccessExpression pattern of human SERPINE2 in a variety of human tumors
Author(s) -
Ying Yang,
Xiangke Xin,
Xing Fu,
Danmei Xu
Publication year - 2018
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2018.7819
Subject(s) - serpin , biology , oncogene , immunohistochemistry , tissue microarray , pathology , cancer research , cancer , computational biology , cell cycle , gene , genetics , immunology , medicine
Serine proteinase inhibitor, clade E member 2 ( SERPINE2 ), also known as protease nexin-1 (PN-1), is a member of the serpin family. Despite several reported roles of SERPINE2 in tumor development the histological distribution of SERPINE2 and its expression levels in a large variety of tumors remains unclear. Through expressed sequence tag database analysis, immunohistochemical staining of tissue microarrays and a literature review, it was revealed that SERPINE2 expression varied according to growth stages and tissue types. SERPINE2 is differentially expressed in a number of tumors and their normal tissue counterparts. SERPINE2 is identified most abundantly in adenocarcinomas. SERPINE2 serves diverse roles in a variety of tumors and therefore may serve as a promising biomarker for tumor diagnosis and prognosis.