Expression pattern of human SERPINE2 in a variety of human tumors | Zendy

Ying Yang | Zendy; Xiangke Xin | Zendy; Xing Fu | Zendy; Danmei Xu | Zendy

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Expression pattern of human SERPINE2 in a variety of human tumors

Author(s) -

Ying Yang,

Xiangke Xin,

Xing Fu,

Danmei Xu

Publication year - 2018

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2018.7819

Subject(s) - serpin , biology , oncogene , immunohistochemistry , tissue microarray , pathology , cancer research , cancer , computational biology , cell cycle , gene , genetics , immunology , medicine

Serine proteinase inhibitor, clade E member 2 ( SERPINE2 ), also known as protease nexin-1 (PN-1), is a member of the serpin family. Despite several reported roles of SERPINE2 in tumor development the histological distribution of SERPINE2 and its expression levels in a large variety of tumors remains unclear. Through expressed sequence tag database analysis, immunohistochemical staining of tissue microarrays and a literature review, it was revealed that SERPINE2 expression varied according to growth stages and tissue types. SERPINE2 is differentially expressed in a number of tumors and their normal tissue counterparts. SERPINE2 is identified most abundantly in adenocarcinomas. SERPINE2 serves diverse roles in a variety of tumors and therefore may serve as a promising biomarker for tumor diagnosis and prognosis.

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