Open AccessMitogen-activated protein kinase signaling pathway in oral cancer (Review)
Author(s) -
Qian Peng,
Zhiyuan Deng,
Hào Pān,
Liqun Gu,
Ousheng Liu,
Zhangui Tang
Publication year - 2017
Publication title -
oncology letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2017.7491
Subject(s) - mapk/erk pathway , signal transduction , protein kinase a , cancer , cancer research , oncogene , cell cycle , metastasis , angiogenesis , biology , kinase , mitogen activated protein kinase , molecular medicine , microbiology and biotechnology , genetics
The mitogen-activated protein kinase (MAPK) signaling pathway is associated with tumor cell proliferation, differentiation, apoptosis, angiogenesis, invasion and metastasis. The present review assesses the involvement of the MAPK signaling pathway in oral cancer progression and invasion based on analysis of individual sub-pathways and their mechanisms of action. The regulation of this pathway for targeted oral cancer therapy is explored and the challenges confronting this, as well as corresponding potential solutions, are discussed. Exploring this pathway with an emphasis on its components, subfamilies, sub-pathways, interactions with other pathways and clinical practice modes may improve oral cancer treatment.