Open AccessNovel insight into MALAT-1 in cancer: Therapeutic targets and clinical applications
Author(s) -
Danyang Ren,
Huiying Li,
LI Ren-qiu,
Jianming Sun,
Pingyi Guo,
Hui-yun Han,
Ying Yang,
Jun Li
Publication year - 2016
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2016.4138
Subject(s) - oncogene , gene silencing , biology , metastasis , cancer research , cancer , cell cycle , adenocarcinoma , molecular medicine , long non coding rna , lung cancer , meg3 , cell growth , cell , bioinformatics , gene , medicine , oncology , genetics , rna
Long non-protein-coding RNAs (lncRNAs) are emerging as important gene expression regulators that are linked to various biological processes at the post-transcriptional and transcriptional levels. lncRNAs are known to be important in cell proliferation, cell differentiation, apoptosis and metastasis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a novel lncRNA, is highly conserved amongst mammals. In addition, it has been considered to act as an oncogene, depending on the tumor system. An increasing number of studies have indicated that MALAT-1 may be detected in certain types of human tumors, including lung and bladder cancer and hepatocellular carcinoma. MALAT-1 silencing may be an effective therapeutic approach against tumors. The present study reviews the current knowledge on the functional role of MALAT-1 in the control of various cancers.