Association between functional variants in BIRC5/survivin gene 3′ untranslated region and mRNA expression in lymphoblastoid cell lines | Zendy

Feifei Pu | Zendy; Zengwu Shao | Zendy; Shuhua Yang | Zendy; Jianxiang Liu | Zendy; Song Lin | Zendy; Xiucai Ma | Zendy; HAOFEI YANG | Zendy

Open Access

Association between functional variants in BIRC5/survivin gene 3′ untranslated region and mRNA expression in lymphoblastoid cell lines

Author(s) -

Feifei Pu,

Zengwu Shao,

Shuhua Yang,

Jianxiang Liu,

Song Lin,

Xiucai Ma,

HAOFEI YANG

Publication year - 2015

Publication title -

oncology letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.766

H-Index - 54

eISSN - 1792-1082

pISSN - 1792-1074

DOI - 10.3892/ol.2015.3507

Subject(s) - survivin , oncogene , microrna , untranslated region , gene , three prime untranslated region , biology , cancer research , five prime untranslated region , inhibitor of apoptosis , microbiology and biotechnology , gene expression , messenger rna , cell cycle , regulation of gene expression , apoptosis , genetics , programmed cell death

Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5)/survivin genetic microRNA (miRNA) binding site variants in the 3' untranslated region (3'UTR) are known to be significantly associated with cancer risk. However, the roles of genetic variants in BIRC5/survivin gene 3'UTRs and post-transcriptional regulation have not been elucidated. In the present study, we revealed that rs1042489, rs1042542, rs17882360, rs2239680, rs2661694 and rs4789560 in the BIRC5/survivin 3'UTR have potential miRNA binding sites using bioinformatics analysis. However, only rs1042489 was significantly associated with BIRC5/survivin mRNA expression in lymphoblastoid cell lines (P=0.030); rs1042489 may be a putative variant mediating the post-transcriptional regulation of the target BIRC5/survivin gene. An in-depth understanding of how 3'UTR variants regulate BIRC5/survivin activity is expected to pave the way to targeting the BIRC5/survivin pathway in cancer therapy.

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