
Association between functional variants in BIRC5/survivin gene 3′ untranslated region and mRNA expression in lymphoblastoid cell lines
Author(s) -
Feifei Pu,
Zengwu Shao,
Shuai Yang,
Jianxiang Liu,
ShiuRu Lin,
Xiucai Ma,
Haofei Yang
Publication year - 2015
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2015.3507
Subject(s) - survivin , oncogene , microrna , untranslated region , gene , three prime untranslated region , biology , cancer research , five prime untranslated region , inhibitor of apoptosis , microbiology and biotechnology , gene expression , messenger rna , cell cycle , regulation of gene expression , apoptosis , genetics , programmed cell death
Baculoviral inhibitor of apoptosis repeat-containing 5 (BIRC5)/survivin genetic microRNA (miRNA) binding site variants in the 3' untranslated region (3'UTR) are known to be significantly associated with cancer risk. However, the roles of genetic variants in BIRC5/survivin gene 3'UTRs and post-transcriptional regulation have not been elucidated. In the present study, we revealed that rs1042489, rs1042542, rs17882360, rs2239680, rs2661694 and rs4789560 in the BIRC5/survivin 3'UTR have potential miRNA binding sites using bioinformatics analysis. However, only rs1042489 was significantly associated with BIRC5/survivin mRNA expression in lymphoblastoid cell lines (P=0.030); rs1042489 may be a putative variant mediating the post-transcriptional regulation of the target BIRC5/survivin gene. An in-depth understanding of how 3'UTR variants regulate BIRC5/survivin activity is expected to pave the way to targeting the BIRC5/survivin pathway in cancer therapy.