Open AccessRisk assessment of mouse gastric tissue cancer induced by dichlorvos and dimethoate
Author(s) -
Qinglu Wang,
Yujun Zhang,
Zhou Chun,
Jie Zhang,
Ye Dou,
Qiaoqiao Li
Publication year - 2013
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2013.1155
Subject(s) - dichlorvos , dimethoate , oncogene , cancer , hematocrit , biology , toxicology , toxicity , saline , andrology , chemistry , cell cycle , pesticide , medicine , endocrinology , genetics , agronomy
Cancer hazards from pesticide residues in food have been much discussed in the past decade. In this study, we showed that dichlorvos and dimethoate affect hemoglobin content and hematocrit value, but had no effect on red blood cell counts and total plasma protein in mice. A 40-mg/kg/day dose of dichlorvos upregulated the expression of p16 , Bcl-2 and c-myc genes in mouse gastric tissue. By contrast, expression of the p16 , Bcl-2 and c-myc genes induced by low doses (5, 10 and 20 mg/kg/day) of dichlorvos demonstrated no change in the control check group (CK; 200 μ l sterile saline perfused group; 0 mg/kg/day). Different doses of dimethoate all upregulated the expression of p16 , Bcl-2 and c-myc genes in mouse gastric tissue. The results further demonstrated that mouse gastric tissue, exposed in the long-term to low doses of dichlorvos and dimethoate, has the potential to become cancerous.