Open AccessEffects of tubeimoside-1 on the proliferation and apoptosis of BGC823 gastric cancer cells in vitro
Author(s) -
Yi Zhang,
Xiaoman Xu,
Meng Zhang,
Dan Qu,
Niu Huang,
Xue Bai,
Liang Kan,
Ping He
Publication year - 2013
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2013.1117
Subject(s) - apoptosis , cancer , oncogene , cell cycle , cancer cell , traditional medicine , cell growth , cell , flow cytometry , biology , in vitro , cancer research , pharmacology , medicine , microbiology and biotechnology , biochemistry , genetics
Natural products isolated from Chinese medicinal herbs are useful sources of new drugs for cancer therapy. Tubeimoside-1 (TBMS1) is a natural compound isolated from the Chinese medicinal herb Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae). Studies have shown that TBMS1 has anticancer effects in various human cancer cell lines. However, the effect of TBMS1 on human gastric cancer cells is unknown. In the present study, it was observed that TBMS1 inhibited BGC823 gastric cancer cell proliferation in a concentration- and time-dependent manner. Fluorescent microscopy and flow cytometric analysis showed that TBMS1 induced BGC823 cell apoptosis in a concentration-dependent manner. Western blot analysis also showed that TBMS1 induced apoptosis by regulation of the Bcl-2 gene family in BGC823 cells. These findings indicate that TBMS1 may be developed as a possible therapeutic agent for the management of gastric cancer.