Open AccessCell cycle-related kinase in carcinogenesis
Author(s) -
Ye Tian,
Han Wan,
Guang Tan
Publication year - 2012
Publication title -
oncology letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2012.828
Subject(s) - cell cycle , cyclin dependent kinase , biology , carcinogenesis , cyclin dependent kinase 7 , kinase , cyclin dependent kinase 4 , wnt signaling pathway , microbiology and biotechnology , cancer research , cyclin dependent kinase 2 , cancer , protein kinase a , signal transduction , genetics
Cell cycle-related kinase (CCRK) is a novel protein kinase homologous to both cyclin-dependent kinase 7 (Cdk7) and Cak1p groups of CDK-activating kinase (CAK). CCRK activates Cdk2, which controls the cell-cycle progression by phosphorylating a threonine residue conserved in Cdk2. Previous studies have indicated that the CCRK protein levels were elevated by more than 1.5-fold in tumor tissue, and that the overexpression of CCRK is associated with poor prognosis of the patients. Moreover, recent studies have shown that CCRK is involved in the Wnt signaling pathway associated with the genesis and evolution of cancer. This review aims to systematically present the information currently available on CCRK obtained from in vitro and in vivo studies and highlight its significance to tumorigenesis.