Open AccessIdentification of serum amyloid A in the serum of gastric cancer patients by protein expression profiling
Author(s) -
Chibo Liu,
Chunqin Pan,
Jianmin Shen,
Haibao Wang,
Yong Liang
Publication year - 2012
Publication title -
oncology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.766
H-Index - 54
eISSN - 1792-1082
pISSN - 1792-1074
DOI - 10.3892/ol.2012.664
Subject(s) - biomarker , oncogene , serum amyloid a , molecular medicine , cancer , medicine , serum amyloid a protein , pathology , gastroenterology , chemistry , cell cycle , biochemistry , inflammation
The purpose of this study was to screen serum samples from gastric carcinoma patients and to determine whether serum amyloid A protein (SAA) served as a biomarker. SELDI technology was used to screen for changes in SAA levels in the serum samples. A mass cluster with a mass/charge (m/z) value between 11.1 and 11.9 kDa was identified in the serum samples from gastric carcinoma patients which was much higher than that of the control group. Furthermore, the increase in this m/z peak correlated with the severity of the cancer. High-performance liquid chromatography (HPLC) analysis confirmed that the peak was SAA1. In conclusion, this increase in SAA may be used as a potential biomarker for gastric cancer.