Open AccessExpression levels of specific microRNAs are increased after exercise and are associated with cognitive improvement in Parkinson's disease
Author(s) -
Franciele Cascaes da Silva,
Michele Patrícia Rode,
Giovanna Grünewald Vietta,
Rodrigo da Rosa Iop,
Tânia Beatriz Creczynski-Pasa,
Alessandra Swarowsky Martin,
Rudney da Silva
Publication year - 2021
Publication title -
molecular medicine reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.727
H-Index - 56
eISSN - 1791-3004
pISSN - 1791-2997
DOI - 10.3892/mmr.2021.12257
Subject(s) - cognition , disease , physical exercise , microrna , physical therapy , medicine , cycle ergometer , psychology , physical medicine and rehabilitation , heart rate , biology , blood pressure , psychiatry , biochemistry , gene
There is a consensus regarding the efficacy of physical exercise in maintaining or improving human health; however, there are few studies examining the effect of physical exercise on the expression levels of microRNAs (miRNA/miRs) in Parkinson's disease (PD). The aim of the present study was to investigate the effects of an interval training program on a cycle ergometer on the expression levels of miR‑106a‑5p, miR‑103a‑3p and miR‑29a‑3p in serum samples from men with PD. This was a quasi‑experimental study with pre‑ and post‑testing and with a non‑equivalent group design. The participants were selected based on the eligibility criteria and subsequently classified into two groups: Experimental group and control group. The evaluations were performed at the beginning of the study (week 0) and after 8 weeks of the intervention program (week 9). The interval training program was performed on a cycle ergometer for 30 min, three times a week during an 8‑week period. The expression levels of miR‑106a‑5p, miR‑103a‑3p and miR‑29a‑3p in the experimental group were increased after physical exercise and were associated with cognitive improvement in men with PD. However, further studies are required to clarify the potential use of these circulating miRNAs as markers of adaptation to physical exercise. Collectively, the present results indicated that these three miRNAs may be associated with the exercise response and cognitive improvement in men with PD.